The primary objective of the proposed systematic review is to answer the following research question: do parenting programmes for parents of adolescents impact adolescent mental health outcomes, positive development and the parent-adolescent relationship? This will be achieved by systematically searching for and synthesising the extant evaluation evidence that meets the inclusion criteria for this review. The secondary objective is to answer the research question: does the impact of parenting programmes for parents of adolescents on adolescent mental health outcomes, positive development, and the parent-adolescent relationship vary by: (1) diagnosis; (2) sociodemographic risk status (e.g., family structure, household income); (3) type of caregiver (e.g., biological parent, foster carer, kinship caregiver); (4) geographical location of the study; (5) intervention setting and modality; (6) type of outcome measurement modality (e.g., observation, self-report); (7) type of intervention model (prevention, early intervention, treatment, theoretical framework); (8) participant age (parent and/or adolescent); and/or (9) participant gender (parent and/or adolescent)? This systematic review has direct relevance to policy within the authors' country of residence (Australia) and internationally. Child and adolescent health and/or mental health policies around the world emphasise the importance of the adolescent period as a critical transition point in the prevention and treatment of mental health problems and the promotion of health and wellbeing, along with the importance of evidence-based interventions and the influential role. This review will provide evidence-based information for the action of "enhancing and promoting resources and mechanisms to support parenting in the middle years and adolescence," which was identified as a neglected and less-resourced area but still an influential period of transition where protective parenting has a strong impact on outcomes; and, for "tackling mental health and risky behaviours, such as building social and emotional coping skills in the middle years and during the transitions into adolescence and early adulthood" within the recently released Australian Government's National Action Plan for the Health of Children and Young People (2020-2030). The findings from this review will support action within identified priority areas for governments across the world.