This paper presents air quality and ventilation data from an existing chemical laboratory facility and discusses the work practice changes implemented in response to deficiencies in ventilation. General methods for improving air quality in existing laboratories are presented and investigation techniques for characterizing air quality are described. The paper also reviews major design considerations for good indoor air quality in new laboratories; two recently designed projects are used as examples. The program document, used by architects and engineers to design a building according to the requirements of the facility's users, is explained as it relates to indoor air quality. Further discussed is how the program information is translated into design strategies and equipment selection for good indoor air quality. The paper concludes with a summary of conditions which often contribute to poor air quality in laboratories and suggestions for addressing these situations. (GR)