Background: Multilevel randomized controlled trials (MRCTs) have been widely used to evaluate the causal effects of educational interventions. Traditionally, educational researchers and policymakers focused on the average treatment effects (ATE) of the intervention. Recently there has been an increasing interest in evaluating the heterogeneity of…

Combining observational and experimental data for causal inference can improve treatment effect estimation. However, many observational data sets cannot be released due to data privacy considerations, so one researcher may not have access to both experimental and observational data. Nonetheless, a small amount of risk of disclosing sensitive…

Evidence-based medicine (EBM) is helpful for laypersons' decision-making. This study aimed to evaluate the effectiveness of e-learning materials on the essential components of EBM for laypersons. We conducted a web-based, open-label, randomized controlled trial with laypersons in Japan aged [greater than or equal to]20 years who used the internet.…

In early 2021-22, the Flexible Phonics reading intervention, a large-scale randomised controlled trial, took place in 118 schools in England and involved nearly 3,000 children. This study aimed to provide valuable insights into the success of largely school-based education trials. The Flexible Phonics trial proved to be not only an important…

Implementation intentions are self-regulatory strategies that increase the probability that desired goals will be achieved. While their effectiveness in the short term is well established in the literature, the long-term effects are not. The present study, which was conducted in France during the COVID-19 lockdown, aimed to test whether reminders…

Many randomized controlled trials have investigated the role of school-based prevention interventions to reduce symptoms of anxiety and depression in young people. Systematic reviews have subsequently demonstrated a small, beneficial effect of these interventions when compared to a combined control group including usual care, no intervention, or…

Introduction: Registration of clinical trials has been initiated in order to assess adherence of the reported results to the original trial protocol. This study aimed to investigate the publication rates, timely dissemination of results, and the prevalence of consistency in hypothesis, sample size, and primary endpoint of Dutch…

During drug development, a biomarker is sometimes identified as separating a patient population into those with more and those with less benefit from evaluated treatments. Consequently, later studies might be targeted, while earlier ones are performed in mixed patient populations. This poses a challenge in evidence synthesis, especially if only…

An emerging body of research suggests that incorporating randomization schemes in single-case research designs strengthens study internal validity and data evaluation. The purpose of this study was to test the utility and feasibility of a randomized alternating-treatment design in an investigation that compared the combined effects of vocabulary…

Perfectionism has adverse impacts on mental health and academic outcomes. We evaluated a 5-lesson classroom intervention for young adolescents delivered by teachers for impact on perfectionism, well-being, self-compassion, academic motivation and negative affect, at post-intervention and 3-month follow-up. Classes (N = 636 students, M[subscript…

Tender Shoots is a randomized controlled trial (RCT) for parents aimed at improving preschool children's oral language skills relevant for later reading. Parents of 72 preschool children (M = 50 months) were randomly assigned to either a Rich Reading and Reminiscing (RRR) condition, a Strengthening Sound Sensitivity (SSS) condition, or an…

Background: Compensatory cleft speech disorders can severely impact speech understandability and speech acceptability. Speech intervention is necessary to eliminate these disorders. There is, however, currently no consensus on the most effective speech therapy approach to eliminate the different subtypes of compensatory cleft speech disorders.…

Background: An efficacy study based on a randomized controlled trial (RCT) was designed to evaluate the impact of ASSISTments on math learning among middle school students, including those from high-needs rural schools. Despite extensive recruitment efforts in 2021 (during the pandemic), only a few schools and their teachers agreed to participate,…

This is a technical report detailing the analytic methods used to assess the effects of a virtual professional learning community (vPLC)-enhanced ASSISTments intervention. The report uses a quasi-experimental design and partially nested regression model to account for clustering and reveals that while overall effects were positive but not…

The gold-standard for evaluating the effect of an educational intervention on student outcomes is running a randomized controlled trial (RCT). However, RCTs may often be small due to logistical considerations, and resulting treatment effect estimates may lack precision. Recent methods improve experimental precision by incorporating information…