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Huston, John C.; Thom, Robyn P.; Ravichandran, Caitlin T.; Mullett, Jennifer E.; Moran, Carly; Waxler, Jessica L.; Pober, Barbara R.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2022
The purpose of the study was to characterize repetitive phenomena in Williams syndrome (WS). The parents of 60 subjects with WS completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) or Children's Y-BOCS, the Yale Global Tic Severity Scale, the Stereotyped Behavior Scale, and the Spence Children's Anxiety Scale--Parent Version. Nineteen…
Descriptors: Genetic Disorders, Intellectual Disability, Congenital Impairments, Repetition
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Bradshaw, Jessica; Gillespie, Scott; McCracken, Courtney; King, Bryan H.; McCracken, James T.; Johnson, Cynthia R.; Lecavalier, Luc; Smith, Tristram; Swiezy, Naomi; Bearss, Karen; Sikich, Linmarie; Donnelly, Craig; Hollander, Eric; McDougle, Christopher J.; Scahill, Lawrence – Journal of Autism and Developmental Disorders, 2021
Parents of children with autism spectrum disorder (ASD) face higher levels of caregiver strain compared to parents of children with other disabilities. This study examined child clinical features that predict high levels of caregiver strain for 374 parents of children with ASD. Caregiver strain was measured using the Caregiver Strain Questionnaire…
Descriptors: Predictor Variables, Stress Variables, Caregivers, Parents
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Criado, Kristen K.; Sharp, William G.; McCracken, Courtney E.; De Vinck-Baroody, Oana; Dong, Liansai; Aman, Michael G.; McDougle, Christopher J.; McCracken, James T.; Eugene Arnold, L.; Weitzman, Carol; Leventhal, John M.; Vitiello, Benedetto; Scahill, Lawrence – Autism: The International Journal of Research and Practice, 2018
Overweight and obesity are common in pediatric populations. Children with autism spectrum disorder and disruptive behavior may be at higher risk. This study examined whether children with autism spectrum disorder and disruptive behavior are more likely to be overweight or obese than matched controls. Baseline data from medication-free children…
Descriptors: Obesity, Body Weight, Children, Autism
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Scahill, Lawrence; Hallett, Victoria; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Tierney, Elaine; Deng, Yanhong; Dziura, James; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2013
There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to…
Descriptors: Autism, Pharmacology, Effect Size, Pervasive Developmental Disorders
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Farmer, Cristan; Lecavalier, Luc; Yu, Sunkyung; Arnold, L. Eugene; McDougle, Christopher J.; Scahill, Lawrence; Handen, Benjamin; Johnson, Cynthia R.; Stigler, Kimberly A.; Bearss, Karen; Swiezy, Naomi B.; Aman, Michael G. – Journal of Autism and Developmental Disorders, 2012
The Research Units on Pediatric Psychopharmacology-Autism Network reported additional benefit when adding parent training (PT) to antipsychotic medication in children with autism spectrum disorders and serious behavior problems. The intent-to-treat analyses were rerun with putative predictors and moderators. The "Home Situations…
Descriptors: Behavior Problems, Autism, Hyperactivity, Predictor Variables
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Chowdhury, Monali; Aman, Michael G.; Lecavalier, Luc; Smith, Tristram; Johnson, Cynthia; Swiezy, Naomi; McCracken, James T.; King, Bryan; McDougle, Christopher J.; Bearss, Karen; Deng, Yanhong; Scahill, Lawrence – Autism: The International Journal of Research and Practice, 2016
Previously, we adapted the Home Situations Questionnaire to measure behavioral non-compliance in everyday settings in children with pervasive developmental disorders. In this study, we further revised this instrument for use in autism spectrum disorder and examined its psychometric properties (referred to as the Home Situations…
Descriptors: Factor Structure, Psychometrics, Questionnaires, Pervasive Developmental Disorders
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Aman, Michael G.; McDougle, Christopher J.; Scahill, Lawrence; Handen, Benjamin; Arnold, L. Eugene; Johnson, Cynthia; Stigler, Kimberly A.; Bearss, Karen; Butter, Eric; Swiezy, Naomi B.; Sukhodolsky, Denis D.; Ramadan, Yaser; Pozdol, Stacie L.; Nikolov, Roumen; Lecavalier, Luc; Kohn, Arlene E.; Koenig, Kathleen; Hollway, Jill A.; Korzekwa, Patricia; Gavaletz, Allison; Mulick, James A.; Hall, Kristy L.; Dziura, James; Ritz, Louise; Trollinger, Stacie; Yu, Sunkyung; Vitiello, Benedetto; Wagner, Ann – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Many children with pervasive developmental disorders (PDDs) have serious, functionally impairing behavioral problems. We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs. Method:…
Descriptors: Behavior Problems, Pervasive Developmental Disorders, Hyperactivity, Disabilities
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Handen, Benjamin L.; Melmed, Raun D.; Hansen, Robin L.; Aman, Michael G.; Burnham, David L.; Bruss, Jon B.; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2009
Controversy exists regarding the extent and possible causal relationship between gastrointestinal symptoms and autism. A randomized, double-blind, placebo-controlled, parallel groups, dose-ranging study of oral, human immunoglobulin (IGOH 140, 420, or 840 mg/day) was utilized with 125 children (ages 2-17 years) with autism and persistent GI…
Descriptors: Autism, Children, Human Body, Drug Therapy
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Dartnall, Nancy A.; Holmes, Janice P.; Morgan, Susan Naylor; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 1999
Presents information on 24 and 34 months of successful treatment with Risperidone of a young woman and young man with autism and profound mental retardation. Treatment with Risperidone resulted in positive changes for aggressive, self-injurious, and anti-social behavior. After treatment, subjects were able to participate in social activities. (CR)
Descriptors: Adults, Aggression, Antisocial Behavior, Autism
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Williams, Susan K.; Scahill, Lawrence; Vitiello, Benedetto; Aman, Michael G.; Arnold, L. Eugene; McDougle, Christopher J.; McCracken, James T.; Tierney, Elaine; Ritz, Louise; Posey, David J.; Swiezy, Naomi B.; Hollway, Jill; Cronin, Pegeen; Ghuman, Jaswinder; Wheeler, Courtney; Cicchetti, Domenic; Sparrow, Sara – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change. Method: Forty-eight children (5 years to 16 years, 5 months) who showed behavioral improvement during acute…
Descriptors: Daily Living Skills, Behavior Problems, Socialization, Autism