Optimal design of multisite randomized trials leverages sampling costs to optimize sampling ratios and ultimately identify more efficient and powerful designs. Past implementations of the optimal design framework have assumed that costs of sampling units are equal across treatment conditions. In this study, we developed a more flexible optimal…

Researchers often include covariates when they analyze the results of randomized controlled trials (RCTs), valuing the increased precision of the estimates over the potential of inducing small-sample bias when doing so. In this paper, we develop a sufficient condition which ensures that the inclusion of covariates does not induce small-sample bias…