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Amnesia or Retrieval Deficit? Implications of a Molecular Approach to the Question of Reconsolidation
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Miller, Courtney A.; Sweatt, J. David – Learning & Memory, 2006
Post-retrieval interference with a memory has uncovered a phenomenon known to the field as reconsolidation. In this article, we will review the specific molecular mechanisms that have been implicated in reconsolidation. As a result of numerous studies over the past five years, it can now be said with a fair amount of certainty that reconsolidation…
Descriptors: Science Experiments, Molecular Biology, Neurology, Learning Processes
Isoform Specificity of Protein Kinase Cs in Synaptic Plasticity
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Sossin, Wayne S. – Learning & Memory, 2007
Protein kinase Cs (PKCs) are implicated in many forms of synaptic plasticity. However, the specific isoform(s) of PKC that underlie(s) these events are often not known. We have used "Aplysia" as a model system in order to investigate the isoform specificity of PKC actions due to the presence of fewer isoforms and a large number of documented…
Descriptors: Biochemistry, Molecular Biology, Physiology, Structural Analysis (Science)
Retrieval Failure versus Memory Loss in Experimental Amnesia: Definitions and Processes
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Miller, Ralph R.; Matzel, Louis D. – Learning & Memory, 2006
For at least 40 years, there has been a recurring argument concerning the nature of experimental amnesia, with one side arguing that amnesic treatments interfere with the formation of enduring memories and the other side arguing that these treatments interfere with the expression of memories that were effectively encoded. The argument appears to…
Descriptors: Data Interpretation, Convergent Thinking, Recall (Psychology), Retention (Psychology)