Down syndrome is one of the leading causes of intellectual disability, and individuals with Down syndrome experience various health issues including learning and memory deficits, congenital heart diseases, Alzheimer's or other dementias, leukemia, cancers, and Hirschsprung disease. School psychologists have a vital role in the success of students with Down syndrome. Students with Down syndrome are typically qualified for special education services under the intellectual disabilities classification, but other classifications that might be seen are autism, specific learning disability, speech impairment, or other health impairment. Children with Down syndrome might receive their special education services in mainstream/regular education classrooms or be placed in specialized functional life skills classrooms, depending on their needs. Intervention, accommodations, and support services may vary significantly depending on each child's needs. For this reason, it is important for school psychologists and other school personnel to understand this neurodevelopmental disorder and ways in which they may help.