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Zearfoss, N. Ruth; Richter, Joel D.; Berger-Sweeney, Joanne – Learning & Memory, 2006
CPEB is a sequence-specific RNA binding protein that regulates translation at synapses. In neurons of CPEB knockout mice, synaptic efficacy is reduced. Here, we have performed a battery of behavioral tests and find that relative to wild-type animals, CPEB knockout mice, although similar on many baseline behaviors, have reduced extinction of…
Descriptors: Neurological Organization, Animal Behavior, Task Analysis, Cytology