Estimation of within-trial interactions in meta-analysis is crucial for reliable assessment of how treatment effects vary across participant subgroups. However, current methods have various limitations. Patients, clinicians and policy-makers need reliable estimates of treatment effects within specific covariate subgroups, on relative and absolute…

Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the dependence between multiple estimates from the same study. However, standard inference…

In medical sciences, a disease condition is typically associated with multiple risk and protective factors. Although many studies report results of multiple factors, nearly all meta-analyses separately synthesize the association between each factor and the disease condition of interest. The collected studies usually report different subsets of…

Structural equation modeling (SEM) is now a generic modeling framework for many multivariate techniques applied in the social and behavioral sciences. Many statistical models can be considered either as special cases of SEM or as part of the latent variable modeling framework. One popular extension is the use of SEM to conduct linear mixed-effects…

The currently available meta-analytic methods for correlations have restrictive assumptions. The fixed-effects methods assume equal population correlations and exhibit poor performance under correlation heterogeneity. The random-effects methods do not assume correlation homogeneity but are based on an equally unrealistic assumption that the…

Shows how to test the hypothesis that a nonnested model fits a set of predictors when modeling multiple effect sizes in meta-analysis. Illustrates the procedure using data from previous studies of the effectiveness of coaching on performance on the Scholastic Aptitude Test. (SLD)