Water is one of the most common molecules in the universe. Water is polarized, but it has many states besides the normal tetrahedron depicted in standard biology texts. Water is also the most ubiquitous molecule on Earth, the universal solvent. It is the internal and external habitat of cells. Ecologically, water is contiguous with life and the…

A complex terminology developed around the evolutionary concept of adaptation. One definition of adaptation is synonymous with adaptive evolution and denotes a process of population change driven by natural selection resulting in individuals better able to survive and reproduce in a particular environment (compared to the population before the…

In the fall of 2009 and in the spring of 2012, supported by the National Institute of General Medical Sciences (NIGMS) in the National Institutes of Health (NIH), we designed a course "Phylogenetic Analysis and Molecular Evolution" (PAME), the first cross-listed course across three different colleges (College of Arts and Sciences,…

Science teachers and mentors continue to be challenged to meet the high expectations of "A Framework for K-12 Science Education" and the "Next Generation Science Standards." Indeed the Framework urges teachers to help learners "[build] progressively more sophisticated explanations of natural phenomena..." while the…

An inversion polymorphism of the filamin and emerin genes at the tip of the long arm of the human X-chromosome serves as the basis of an investigative laboratory in which students learn something new about their own genomes. Long, nearly identical inverted repeats flanking the filamin and emerin genes illustrate how repetitive elements can lead to…

Although some creationist objections to evolutionary biology are simplistic and thus are easily refuted, when more technical arguments become widespread it is important for science educators to explain the relevant science in a straightforward manner. An interesting case study is provided by misguided allegations about how cytochrome c data…

A logical question to be expected from students: "How could life develop, that is, change, evolve from simple, primitive organisms into the complex forms existing today, while at the same time there is a generally observed decline and disorganization--the second law of thermodynamics?" The explanations in biology textbooks relied upon by…

Teachers may be posed with such questions as, "If we evolved from chimps, why are there still chimps?" We provide teachers with answers to this and related questions in the context of the latest genetic, fossil, and behavioral evidence. We also provide references they can use to further students' understanding of human evolution and evolution in…

Molecular similarity is one of the strongest lines of evidence for evolution--and one of the most difficult for students to grasp. That is because the underlying observations--that identical mutations are found in closely related species and the degree of similarity decreases with evolutionary distance--are not visible to the human eye. And it's…

Using the life sciences, this article first reviews essential features of the "NRC Framework for K-12 Science Education" that provided a foundation for the new standards. Second, the article describes the important features of life science standards for elementary, middle, and high school levels. Special attention is paid to the teaching…

In a flexible multisession laboratory, students investigate concepts of phylogenetic analysis at both the molecular and the morphological level. Students finish by conducting their own analysis on a collection of skeletons representing the major phyla of vertebrates, a collection of primate skulls, or a collection of hominid skulls.

The material in this module introduces students to some of the mathematical tools used to examine molecular evolution. This topic is standard fare in many mathematical biology or bioinformatics classes, but could also be suitable for classes in linear algebra or probability. While coursework in matrix algebra, Markov processes, Monte Carlo…

Reconstructing phylogenies from nucleotide sequences is a challenge for students because it strongly depends on evolutionary models and computer tools that are frequently updated. We present here an inquiry-based course aimed at learning how to trace a phylogeny based on sequences existing in public databases. Computer tools are freely available…

Life as people know it here on Earth exchanges energy and materials with the environment. Life forms grow, develop, produce waste products, and reproduce, storing genetic information in DNA and RNA and passing it from one generation to the next. Life evolves, adapting to changes in the environment and changing the environment in return. The basic…

In order for students to understand genetics and evolution, they must first understand the structure of the DNA molecule. The function of DNA proceeds from its unique structure, a structure beautifully adapted for information storage, transcription, translation into amino acid sequences, replication, and time travel. The activity described in this…