Maternal and infant health indicators are often used to gauge the overall health of a nation. Understanding the current state of maternal and infant well-being, health behaviors, and social determinants of health across several domains offers the opportunity to kindle ideas for interventions to improve well-being. This report features indicators across various domains. Fifteen indicators are highlighted, covering domains related to health, family and social environment, economic circumstances, healthcare, physical environment and safety, and behavior. The health domain covers topics such as maternal vaccination, maternal mortality, and maternal postpartum depressive symptoms. Data sources include California's Maternal and Infant Health Assessment (MIHA), the Pregnancy Risk Assessment Monitoring System (PRAMS), multiple nationwide surveys, and data sets from the National Center for Health Statistics' National Vital Statistics System. This publication provides information on maternal and infant health and mortality for all interested members of the public, including community organizations, policymakers, and students. In addition to indicators of well-being in the report, this special issue also includes a Data Topics section with reference to social determinants of health that may be associated with maternal and infant outcomes. Explanations of the data limitations and further research needed on these measures are provided. Additionally, the report features the At-a-Glance section, a quick reference with an update on data changes for all 41 indicators found in the report.