Monitoring the Future (MTF) is an ongoing research program conducted at the University of Michigan's Institute for Social Research under a series of investigator-initiated research grants from the National Institute on Drug Abuse beginning in 1975. The integrated MTF study includes annual surveys of nationally-representative samples of 8th, 10th, and 12th grade students, as well as a subset of 12th grade students followed into adulthood from each graduating class each year. Repeating these annual cross-sectional surveys over time provides data to examine behavior change across history in consistent age segments of the adult population, as well as among key subgroups. The MTF Panel Study now includes about 120,000 individuals who were first surveyed in 12th grade, with longitudinal data spanning ages 18 to 65. Each year, approximately 20,000 people in the MTF Panel are surveyed across young adulthood (ages 19 to 30), early midlife (ages 35 to 50), and midlife (ages 55 to 65). These data, gathered on national samples over such a large portion of the lifespan, are extremely rare and can provide needed insight into the epidemiology, etiology, and life course history of substance use and relevant behaviors, attitudes, and other factors. The current annual report is the latest in a series of publications dating back to 1986, all available at monitoringthefuture.org. MTF Panel data are available through the National Addiction & HIV Data Archive Program at https://www.icpsr.umich.edu/web/pages/NAHDAP/index.html. The MTF Panel data dashboard is available at https://monitoringthefuture.org/data/panel/.