Biology is perhaps the most complex of the sciences, given the incredible variety of chemical species that are interconnected in spatial and temporal pathways that are daunting to understand. Their interconnections lead to emergent properties such as memory, consciousness, and recognition of self and non-self. To understand how these…

Recently, the field of adaptive learning has significantly attracted researchers' interest. Learning path adaptation problem (LPA) is one of the most challenging problems within this field. It is also a well-known combinatorial optimization problem, its main target is the knowledge resources sequencing offered to a specific learner with a specific…

Compared with the application of Digital Twin (DT) in the industrial field, the application of DT in the field of education is still in its infancy. In this paper, a Digital Twin Campus (DTC) for teaching and learning is proposed. It is argued that DTC possesses two characteristics. First, DTC has a wide variety of employment orientations for…

Simulation studies involving mixture models inevitably aggregate parameter estimates and other output across numerous replications. A primary issue that arises in these methodological investigations is label switching. The current study compares several label switching corrections that are commonly used when dealing with mixture models. A growth…

This paper walks the reader through a simple mathematical characterization of the popular children's game, "Chutes and Ladders," focusing primarily on Monte Carlo simulation. The focus is then shifted to the board game "No Te Enojes" in order to analyze the implications of the introduction of strategy. The presence of strategy…

We investigate two non-iterative estimation procedures for Rasch models, the pair-wise estimation procedure (PAIR) and the Eigenvector method (EVM), and identify theoretical issues with EVM for rating scale model (RSM) threshold estimation. We develop a new procedure to resolve these issues--the conditional pairwise adjacent thresholds procedure…

Optimization is a vital mathematical concept widely applied in various engineering fields. However, teaching this subject to engineering students often involves abstract materials, making it challenging for them to grasp. To address this issue, a group of five mathematics lecturers collaborated on designing a practical lesson on optimization for…

This research aimed to reveal the effectiveness of using a Problem-Based Learning (PBL) physics pocketbook integrating augmented reality (AR) with the local wisdom of catapults in improving the mathematical and graphical representation abilities of high school students. This study is a quasi-experiment with a pretest-posttest control group design.…

Implementing an equity agenda in the classroom is both necessary and challenging for classes containing pre-service teachers. For this intervention, we chose to begin our History of Mathematics course for preservice middle school teachers with a cultural simulation training exercise: Bafa Bafa. After participating in the exercise, pre-service…

The paper discusses a certain type of competitions based on distance interaction of a participant with simulation models of concepts from discrete mathematics and computer science. One of them is the "Construct, Test, Explore" (CTE) competition, developed by the authors, the other is the Olympiad in Discrete Mathematics and Theoretical…

In recent years, the health sector has faced increasingly important challenges. Due to the economic crisis and competitions, hospitals are facing many issues affecting the supply chain, such as budget cuts or lack thereof as well as insufficient human resources. Although essential for an excellent service, logistics take up a considerable part of…

Background: Standard methods for analysing data from large-scale assessments (LSA) cannot merely be adopted if hierarchical (or multilevel) regression modelling should be applied. Currently various approaches exist; they all follow generally a design-based model of estimation using the pseudo maximum likelihood method and adjusted weights for the…

To understand the excitation-contraction (E-C) coupling of cardiomyocytes, including the electrophysiological mechanism of their characteristically long action potential duration, is one of the major learning goals in medical physiology. However, the integrative interpretation of the responses occurring during the contraction-relaxation cycle is…

Gestalt psychologists pointed out about 100 years ago that a key to solving difficult insight problems is to change the mental representation of the problem, as is the case, for example, with solving the six matches problem in 2D vs. 3D space. In this study we ask a different question, namely what representation is used when subjects solve search,…

A maximum marginal likelihood estimation with an expectation-maximization algorithm has been developed for estimating multigroup or mixture multidimensional item response theory models using the generalized partial credit function, graded response function, and 3-parameter logistic function. The procedure includes the estimation of item…