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Direct linkDaly, Caitlin H.; Maconachie, Ross; Ades, A. E.; Welton, Nicky J. – Research Synthesis Methods, 2022
Randomised controlled trials of cancer treatments typically report progression free survival (PFS) and overall survival (OS) outcomes. Existing methods to synthesise evidence on PFS and OS either rely on the proportional hazards assumption or make parametric assumptions which may not capture the diverse survival curve shapes across studies and…
Descriptors: Nonparametric Statistics, Randomized Controlled Trials, Evidence, Networks
Piepho, Hans-Peter; Madden, Laurence V. – Research Synthesis Methods, 2022
Network meta-analysis is a popular method to synthesize the information obtained in a systematic review of studies (e.g., randomized clinical trials) involving subsets of multiple treatments of interest. The dominant method of analysis employs within-study information on treatment contrasts and integrates this over a network of studies. One…
Descriptors: Medical Research, Meta Analysis, Networks, Drug Therapy
