This review aimed to investigate the use of the Cambridge Neuropsychological Automated Testing Battery (CANTAB) for people at risk of cognitive impairment, especially those born with Down syndrome and those born preterm. Six databases were searched according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards,…

Epigenetic modifications of chromatin structure provide a mechanistic interface for gene-environment interactions that impact the individualization of health trajectories across the lifespan. A growing body of research indicates that dysfunctional epigenetic regulation contributes to poor cognitive outcomes among aged populations. Here we review…

Executive function (EF) skills are the attention-regulation skills that make it possible to sustain attention, keep goals and information in mind, refrain from responding immediately, resist distraction, tolerate frustration, consider the consequences of different behaviors, reflect on past experiences, and plan for the future. As EF research…

Huntington's disease (HD), an autosomal-dominant genetic disorder, has historically been viewed as a degenerative movement disorder but it also includes psychiatric symptoms and progressive cognitive decline. There has been a lack of consensus in the literature about whether or not cognitive signs can be detected in carriers before clinical…

It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is…

Discusses work by Arthur Jensen in addition to his well-known work on the genetics of intelligence. Includes studies of learning, memory, the cumulative-deficit hypothesis, Spearman's hypothesis, and the speed of information processing. (SLD)

A review of studies on mental retardation published in the Soviet Union between 1970 and 1980 touches on physical and neurological issues, genetic studies, learning and memory, and emotional factors. General conclusions drawn include that more males are retarded or emotionally disturbed than females. (CL)

Comments on the work of Arthur Jensen, specifically "The g Factor" (1998), which consolidates the psychometric, neurophysiological, behavior genetic, and comparative evidence for the existence and importance of a factor of general intelligence ("g"). Discusses Jensen's work on black/white differences in intelligence. (SLD)

Drawing on research evidence from across the world, this book offers a wide-ranging perspective on the ways in which we understand and study young children. The book summarizes current debates in child development, and looks at different ways of understanding early childhood and the various methods used to gain understanding, featuring: (1)…

The paper consists of a review of 24 studies on mental retardation published in two Soviet journals between 1970 and 1980. An introductory section focuses on the theoretical framework for mental retardation research in the Soviet Union with a differentiation between oligophrenics (who have organic brain damage) and the intellectually backward (or…

Notes that the microgenetic method has revealed new information about normally achieving children's cognition, and reviews data from three different microgenetic studies. Concludes that there are similar sequences of strategy change, similar rates of strategy change, and similar frequency of strategy discovery and use in children with and without…

The monograph reviews federal research activities and progress in biomedical and behavioral/social science research in mental retardation. Activities represent the National Institute of Child Health and Human Development and the Mental Retardation and Developmental Disabilities branch. The following categories are addressed in terms of biomedical…