"The Challenge", a publication of the US Department of Education's office of Safe and Drug-Free Schools, provides critical information and resources to assist schools in creating safe and healthy environments for young people. This issue addresses the following topics: (1) Prevention Programs with Staying Power: What Makes Good Prevention Programs Take Hold and Last?; (2) Indoor Air Quality for Schools: Creating a Healthy Environment for Students and Staff; (3) Understanding the Lists of Effective Programs: Blueprints for Violence Prevention; (4) Senate Confirms Margaret Spellings as Secretary of Education; (5) Funding Forecast: OSDFS Projects FY05 Grant Competitions; (6) Student Drug Testing Update; and (7) Prevention Library: Resources for Further Information on Youth Drug Use, Violence, and Creating Safe and Drug-Free Schools. ["The Challenge" is published by Learning Systems Group under a grant from the U.S. Department of Education's Office of Safe and Drug-Free Schools.]