Chinese international students have consistently constituted the largest international student body in the United States (U.S.) higher education for decades. Due to their prominence in U.S. higher education institutions, it is imperative to closely examine their lived experiences. Existing empirical research demonstrates that plenty of Chinese international students are underserved, coping with issues such as culture shock, linguistic barriers, educational disparities, racial discrimination, and mental health concerns. This systematic literature review aims to: 1) Explore whether Chinese international students face challenges in the U.S. higher education; 2) Categorize the challenges (if present) encountered by Chinese international students in the U.S. higher education; 3) Provide recommendations to key stakeholders in international education, empowering them to refine current administrative policies and teaching pedagogies to better support the well-being of Chinese international students in the U.S. higher education.