Civil war in Syria has resulted in the largest refugee group and the newest wave of refugees resettling in countries worldwide. Although they have experienced war, migration, and great trauma, resettlement introduces a new set of obstacles including cultural adjustment, language learning, and the development of a new social network. This paper is a qualitative analysis of the acculturation, mental health, and academic experience of Syrian refugee adolescents in the United States. The study is unique in its use of an ecological framework to organize emerging themes, and integrates responses from parents and adolescents to provide a comprehensive understanding of this experience. Moreover, the researchers focus on an important setting for support and intervention: the school system. Implications and recommendations for assessment, intervention, and programming are provided.