Drug use in Spain is one of the most serious problems faced by society today, and is particularly relevant in adolescence. Practicing physical sport activity is considered one of the most representative habits of a healthy lifestyle, and can act as a preventive factor in drug use. The physical self-concept of the people who practice sport plays a key role in drug adherence. This study aims to analyze the relation and influence of physical self-concept in drug, tobacco, and cannabis use in a sample of 682 adolescent athletes (M = 15.85; SD = 1.404). The results suggest significant influences on the competition perceived in different drug uses. Some practical implications can be deduced for coaches and instructors to bear in mind for their athletes, who aim to acquire a more adaptive and self-determined behavior away from drug use.