The majority of this essay describes the content, pedagogy, and assessments associated with an undergraduate, interdisciplinary honors seminar on science and religion. The seminar is structured around five major themes: (a) philosophy of science, religion, and their interactions, (b) historical and contemporary case studies, (c) the controversy over biological evolution in the United States as a necessary case study, (d) comparative religion and science, and (e) contemporary issues at the intersection of science and religion. I also describe the consistency between the seminar and the mission of the honors college at my institution. Given the prominence of both science and religion in contemporary culture, I assert that such a course is engaging for students and faculty alike and provides opportunities for multidisciplinary involvement.