An organization's ability to accomplish its mission is often contingent upon its collective capacity to execute projects and/or initiatives in a timely and organized manner. Project management has a critical role in the delivery of projects within designated timelines, budgets, and defined quality. Duke University, in its entirety, comprises both its university campus and a growing health system. The organizational complexity of this enterprise necessitated the creation of a shared resource and platform for project managers across the institution to come together to share ideas, best practices, network, and engage in opportunities for professional development to better support the University's research mission. The mission of the Duke Project Management Community of Practice (Duke PMCoP) is to provide a professional network for project managers, including professional development activities; education and training for students, faculty, and staff; and a repository for best practices, tools, and resources in project management. In just over two years from its official launch, the Duke PMCoP has evolved into an active and robust community and boasts over 400 members participating from across Duke University and the local Veterans Affairs Health Care System in Durham, NC. This manuscript describes the development and implementation of the Duke PMCoP, in the context of the successes, challenges, and lessons learned during its establishment in a large, academic health system. Moving forward, the focus of the PMCoP is to sustain and grow the community to achieve recognition as the primary resource for project management expertise and mentorship across campus.