The Science Teaching Excites Medical Interest (STEMI) program is an evolving collaboration of academic health science center-based biomedical clinical and research experts, graduate students in clinical anatomy, and Mississippi K-12 schools that seeks to develop a technologically-enhanced teacher-centered community of health learners. The present description of the STEMI community highlights development, implementation, and initial dissemination of high school learning products utilizing contemporary technological approaches and the flipped classroom pedagogical model. The goal is to better engage students within a context of exploring relationships between health literacy, the state's epidemic of obesity, and ensuing anatomic and functional pathophysiology. An evaluation team utilizes a robust mixed-methods approach to examine the program goals and the potential for program expansion and replication. The community is growing, in part through a robust collaboration with the Mississippi INBRE (IDeA Network of Biomedical Research Excellence) at the University of Southern Mississippi.