Trauma-informed sex education is sensitive to students' traumatic life experiences. Internet panel data for 600 Louisiana parents/caregivers of school-age youth were used to examine parental support for trauma-informed school-based sex education, and parental characteristics associated with supporting trauma-informed sex education. Nearly three-quarters (71%) of parents agreed that youth are exposed to high levels of trauma, and 86% reported interest in school-based sex education that supports emotional wellness. Of all parental characteristics, the perception that youth are exposed to high levels of trauma was most strongly associated with endorsement of trauma-informed sex education. Louisiana parents recognize the influence of emotional wellness on youth sexual health and support trauma-informed school-based sex education, which is becoming the new standard for youth sex education services.