As international student enrollments surge in U.S. higher education, understanding their experiences is crucial for fostering an inclusive and successful environment. This study used a hermeneutic phenomenological approach to explore the challenges and coping strategies of international students during acculturation. Data were collected through in-depth interviews with eight international graduate students from diverse backgrounds at a large U.S. public research-based university. An inductive, hermeneutic approach revealed six main challenges: (1) cultural differences and adjustment, (2) practical and daily living, (3) academic and educational, (4) mental health and well-being, (5) linguistics and communication barriers, and (6) lack of resources. Students reported resilience strategies and four main coping mechanisms and needs for better adjustment: (1) building connections and social support, (2) cultivating resilience and personal development, and (3) leveraging technology and media. The findings of this research highlight the importance of social support and self-resilience for international students.