This study sought to develop the College Mental Health Scale (CMHS) as a screening instrument among Iranian college students. In total, the nationally representative sample (N = 74,571) was selected to match the Iranian college student population throughout the country. In the first study, a conceptual framework was developed and a pool of items based on the most prevalent mental disorders in Iranian college students were devised. In the second study, psychometric properties of CMHS was examined (n = 600). The third study was conducted in two phases. In the first phase (n = 2,750), explanatory factor analysis was used for reaching a better factor structure and in the second phase (n = 2,750) the invariability of factor structure and correlation of CMHS with related measure was examined. The result revealed a 56-item measurement scale consisting of seven dimensions as the most prevalent mental disorders. In the fourth study (n = 68,471), male and female norms were developed. The CMHS has adequate reliability and validity and can be used for assessment of college students' mental health problems in Iran.