The quality of the education system is the foremost factor for the success of the students as well as the academia at large, and therefore, needs the focus of regulators and researchers alike. The current article investigates into the role of human resource (HR) quality and Kaizen on the quality assurance system in the context of the high school environment in Indonesia. The current research also analyzes the moderating role of national higher education policies among the associations of HR quality, Kaizen and the quality assurance system in the high school environment in Indonesia. The primary sources of data collection have been adopted by the researchers using survey questionnaires. The medical students are the respondents targeted by the researchers selected based on purposive sampling. The researchers have adopted primary data analysis tools such as Smart-PLS to test the hypotheses and check the validity and reliability of the items and constructs. The findings indicated that HR quality and Kaizen have a positive association with quality assurance systems within the high school environment in Indonesia. The outcomes also revealed that national higher education policies significantly moderate among the association of HR quality, Kaizen and quality assurance system in the high school environment in Indonesia. These outcomes provide valuable insights for policymaking regarding assessment and improvement of the quality assurance system in the education sector in the country.