The authors are a group of Western-trained biologists (seven students and one faculty member) from diverse cultural backgrounds, who spent a semester exploring how they might complement their epistemological approach to addressing real-world problems by including possibilities outside the Western-scientific methodology. Their study focused on how to move towards a multicultural scientific approach through the ethical, authentic inclusion of Indigenous Science. Their reflections were informed by literature review and conversations with Indigenous and Western scientists at various stages in their careers. The authors are hopeful that through continuing conversations with scientists, cultural experts, and Indigenous communities, we can make progress towards advancing a multicultural approach to scientific exploration through ethical engagement with Indigenous people.