America's regional public universities (RPUs) serve a unique role as the portal through which so many students and the nation's future workforce gain the skills needed to face the economic challenges of the 21st century. RPU programs offer 4.9 million students, who are increasingly of color, low income, first generation, and working adults, the opportunity to achieve America's promise of an affordable, high-quality college education. And across the country, RPUs serve as indispensable venues for access and civic engagement. In addition, as institutions are created by and accountable to the states, they serve as catalysts for economic growth in their communities and as engines of global competitiveness for the nation. Considering the challenges RPUs face, including shrinking budgets, increased demand for affordable postsecondary education, enrollment volatility, and onerous regulations, we must persevere to create opportunities for all students who would otherwise have few real options for realizing the American Dream--a satisfying career and a fulfilling life. The American Association of State Colleges and Universities (AASCU) presents its "2025 Public Policy Agenda." It underscores the most compelling policy issues affecting regional public universities and promotes policies that help institutions fulfill their unique role in educating America's workforce and strengthening communities. Each issue has implications for the state, federal, or both levels of policy and law. Accordingly, this report provides state and federal policymakers with specific actions to take going forward.