This guide examines how the Americans with Disabilities Act of 1990 has focused attention on the issue of the relationship between disabilities and the increased risk for alcohol and other drug problems. A number of reasons for increased risk of drug use in individuals with disabilities are discussed, such as medication use, health concerns or chronic pain, peer group differences, fewer social supports, and enabling of alcohol and other drug use. Disability categories identified as at risk for alcohol and other drug use are examined, including attention deficit disorder, blindness and visual impairments, deafness and hearing loss, hidden disabilities, learning disabilities, mental illness, mental retardation, mobility limitations, and traumatic brain injury. The guide then cites needs in the area of drug abuse prevention for this population, including research, access to appropriate prevention information, early identification of problems, and access to appropriate treatment. Activities that can address these issues are noted. The distinction between use, abuse, and dependence is explained. A list of 16 materials available from the Resource Center on Substance Abuse Prevention and Disability is provided. (13 references) (JDD)