A long-term public health goal in the United States involves convincing adolescents to postpone sexual activity or promote responsible sexual activity. This study investigated the effect of using infant simulators on sexuality, child care attitudes and knowledge with a sample of 309 high school students from seven different states. The treatment group included 152 students and the comparison group included 157. Students completed a posttest that assessed their attitudes and knowledge, and completed a follow-up conducted nine months later. The treatment group completed a structured, skill-based curriculum developed by Realityworks and utilized the Realityworks infant simulator. The comparison group completed a curriculum developed by their school districts and did not use the infant simulator. Chi-square analysis was used to analyze posttest and follow-up attitudinal responses, and analysis of variance (ANOVA) was used to compare scores on the cognitive test. Results indicated that the treatment group surpassed the comparison group on attitudes and cognitive achievement on the posttest and these differences were maintained on the follow-up. The results demonstrated the effectiveness of the curriculum and infant simulator. (Contains 3 tables.)