Evidence synthesis findings depend on the assumption that the included studies follow good clinical practice and results are not fabricated or false. Studies which are problematic due to scientific misconduct, poor research practice, or honest error may distort evidence synthesis findings. Authors of evidence synthesis need transparent mechanisms…

Increasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we developed the IPD Integrity Tool to screen randomised controlled trials (RCTs) for integrity issues. Development of the tool involved a literature…

RobotReviewer is a tool for automatically assessing the risk of bias in randomized controlled trials, but there is limited evidence of its reliability. We evaluated the agreement between RobotReviewer and humans regarding the risk of bias assessment based on 1955 randomized controlled trials. The risk of bias in these trials was assessed via two…

Individual participant data (IPD) meta-analysis projects obtain, harmonise, and synthesise original data from multiple studies. Many IPD meta-analyses of randomised trials are initiated to identify treatment effect modifiers at the individual level, thus requiring statistical modelling of interactions between treatment effect and participant-level…

The Campbellian validity typology has been used as a foundation for outcome evaluation and for developing evidence-based interventions for decades. As such, randomized control trials were preferred for outcome evaluation. However, some evaluators disagree with the validity typology's argument that randomized controlled trials as the best design…

Autistic people are more likely to have co-occurring mental health conditions compared to the general population, and mental health interventions have been identified as a top research priority by autistic people and the wider autism community. Autistic adults have also communicated that quality of life is the outcome that matters most to them in…

Many autistic children access some form of early intervention, but little is known about the value for money of different programs. We completed a scoping review of full economic evaluations of early interventions for autistic children and/or their families. We identified nine studies and reviewed their methods and quality. Most studies involved…

Analysis of symmetrically predicted endogenous subgroups (ASPES) is an approach to assessing heterogeneity in an ITT effect from a randomized experiment when an intermediate variable (one that is measured after random assignment and before outcomes) is hypothesized to be related to the ITT effect, but is only measured in one group. For example,…

This article offers a case example of how experimental evaluation methods can be coupled with principles of design-based implementation research (DBIR), improvement science (IS), and rapid-cycle evaluation (RCE) methods to provide relatively quick, low-cost, credible assessments of strategies designed to improve programs, policies, or practices.…

During drug development, a biomarker is sometimes identified as separating a patient population into those with more and those with less benefit from evaluated treatments. Consequently, later studies might be targeted, while earlier ones are performed in mixed patient populations. This poses a challenge in evidence synthesis, especially if only…

In randomized control trials (RCT), the recent focus has shifted to how an intervention yields positive results on its intended outcome. This aligns with the recent push of implementation science in healthcare (Bauer et al., 2015) but goes beyond this. RCTs have moved to evaluating the theoretical framing of the intervention as well as differing…

Network meta-analysis is a popular method to synthesize the information obtained in a systematic review of studies (e.g., randomized clinical trials) involving subsets of multiple treatments of interest. The dominant method of analysis employs within-study information on treatment contrasts and integrates this over a network of studies. One…

This study presents findings from a 58 high-school group-randomized controlled trial testing the effectiveness of training in a multitiered system of supports for behavior (MTSS-B) framework, which was leveraged to reduce students' risk for emotional and behavior disorders. The trial tested the impact of MTSS-B, which included (a) training in the…

Education decisionmakers need access to the best evidence about the effectiveness of education interventions, including practices, products, programs, and policies. It can be difficult, time consuming, and costly to access and draw conclusions from relevant studies about the effectiveness of interventions. The What Works Clearinghouse (WWC)…

Background: Efficacy trials in education often possess a motivating theory of change: how and why should the desired improvement in outcomes occur as a consequence of the intervention? In scenarios with repeated measurements, certain subgroups may be more or less likely to manifest a treatment effect; the theory of change (TOC) provides guidance…