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Direct linkHoffman, Janlyn R.; Brandwein, Nathan J.; Nguyen, Peter V. – Learning & Memory, 2019
Beta-adrenergic receptors ([beta]-ARs) prime hippocampal synapses to stabilize long-term potentiation (LTP). This "metaplasticity" can persist for 1-2 h after pharmacologic activation of [beta]-ARs. It requires activation of PKA (cAMP-dependent protein kinase) during [beta]-AR priming. A-kinase anchoring proteins (AKAPs) tether PKA to…
Descriptors: Animals, Science Experiments, Foreign Countries, Stimulation
Cox, Conor D.; Palmer, Linda C.; Pham, Danielle T.; Trieu, Brian H.; Gall, Christine M.; Lynch, Gary – Learning & Memory, 2017
Humans routinely use past experience with complexity to deal with novel, challenging circumstances. This fundamental aspect of real-world behavior has received surprisingly little attention in animal studies, and the underlying brain mechanisms are unknown. The present experiments tested for transfer from past experience in rats and then used…
Descriptors: Animals, Experiential Learning, Brain, Short Term Memory
