Gene therapy has fascinated clinicians, scientists, and patients since decades ago because of its potential to treat a disease at the genetic level. This can be achieved in many ways, including replacing a disease-causing gene with a healthy copy. Gene therapy must overcome complex tissue and cellular barriers to introduce genetic modifications…

Pediatric cancer is the second leading cause of death among children ages 1-14 (Whitehead et al., 2016). Approximately 10,500 children ages 1-14 and 5090 adolescents ages 15-19 have been diagnosed with cancer in 2021 (American Cancer Society, 2021). An estimated 28% of childhood cases and 13% of adolescent patients will be diagnosed explicitly…

When students think of evolution, they might imagine T. rex, or perhaps an abiotic scene of sizzling electrical storms and harsh reducing atmospheres, an Earth that looks like a lunar landscape. Natural selection automatically elicits responses that include "survival of the fittest," and "descent with modification," and with…

Cancer survivors experience both physical and cognitive changes after treatment that can impact their vocational well-being should they decide to return to work. In this article, we explore the ways in which career counselling interventions can address the challenges faced by cancer survivors as they re-enter the workforce. Four major…

A cancer diagnosis enlivens the question of what it means to live well with the Earth and its multidimensional beings, including the children I teach. A cancer diagnosis provides a necessary push to step out from the confines of a self and toward and into the wild fray of this life. I interpret my lived experiences through the practical philosophy…

Like many children of immigrants, I have provided English language support to my Korean parents for as long as I remember. Up until this summer, I had no trouble translating or providing English support for my dad. But when my dad was diagnosed with metastatic brain cancer in May 2021, it felt like learning a new language, the language of…

The application of chemistry concepts in biological settings plays an important role in the interdisciplinary field of drug discovery and development. This is true for molecular docking, where an understanding of intermolecular forces and noncovalent interactions is useful for rational drug design and development. Here we report the design and use…

Globally, approximately 400,000 youth are diagnosed with pediatric cancer each year. Treatment-related side effects, psychosocial challenges, and frequent school absences may adversely impact learning and the education experience among these youth. Efforts to enhance interagency collaboration between health care settings and community schools are…

Community-engaged patient navigation safety net programs are established as an evidence-based approach to address cancer prevention and early detection efforts, but barriers to expand and sustain such programs persist. In addition, few studies describe how these programs impact buy-in among communities and policy change within health care systems…

Enzymes provide attractive targets for drug development. Quantitative analysis of enzyme reactions can lead to rational drug discovery. For undergraduates majoring in biochemistry or pharmacy and engaged in drug discovery-related work, it is essential to acquire a comprehensive understanding of enzyme kinetics, including experimental methods and…

Formation of eukaryotic initiation factor 4F (eIF4F) is widely considered to be the rate-limiting step in cap-dependent translation initiation. Components of eIF4F are often up-regulated in various cancers, and much work has been done to elucidate the role of each of the translation initiation factors in cancer cell growth and survival. In fact,…

We describe an innovative, semester-long course in biology and communication skills for master's degree students in biostatistics. The primary goal of the course is to make the connection between biological science and statistics more explicit. The secondary goals are to teach oral and written communication skills in an appropriate context for…

One of the important mechanisms in cancer cell metastasis is the cellular function of a specific cell type called myofibroblast cells. Myofibroblast cells are unique cell types that play an important role in the cancer cell microenvironment. As a step toward integrating the latest peer-reviewed cancer research findings into a general biology…

Biological systems exhibit strong dynamic variations; for example, a system may have a tendency towards either a steady state, periodic behaviour or chaotic oscillations. These findings, explained by dynamic systems theory, have allowed researchers to formally relate a wide variety of systems, such as the theory of rumour propagation, glucose…

Viruses are microscopic organisms that require a host to live and multiply. The Human Papillomavirus is a sexually transmitted virus with strains that are connected with cervical cancer and genital warts. Due to the risk of cervical cancer, women have traditionally been "pre-treated" with various vaccinations as a means of prevention.…