Optimal sampling frameworks attempt to identify the most efficient sampling plans to achieve an adequate statistical power. Although such calculations are theoretical in nature, they are critical to the judicious and wise use of funding because they serve as important starting points that guide practical discussions around sampling tradeoffs and…

Conventional optimal design frameworks consider a narrow range of sampling cost structures that thereby constrict their capacity to identify the most powerful and efficient designs. We relax several constraints of previous optimal design frameworks by allowing for variable sampling costs in cluster-randomized trials. The proposed framework…

Researchers are often interested in whether the effects of an intervention differ conditional on individual- or group-moderator variables such as children's characteristics (e.g., gender), teacher's background (e.g., years of teaching), and school's characteristics (e.g., urbanity); that is, the researchers seek to examine for whom and under what…

Recent studies show cluster randomized trials may be well powered to detect mediation or indirect effects in multilevel settings. However, literature has rarely provided guidance on designing cluster-randomized trials aim to assess indirect effects. In this study, we developed closed-form expression to estimate the variance of and the statistical…

Designs that facilitate inferences concerning both the total and indirect effects of a treatment potentially offer a more holistic description of interventions because they can complement "what works" questions with the comprehensive study of the causal connections implied by substantive theories. Mapping the sensitivity of designs to…