Because studies examining youth drug use often have data with a high proportion of zeros, they often do not meet the assumptions for univariate or linear regression analyses that are typically used. We demonstrate the use of zero-inflated negative binomial regression models to address excessive zeros in drug use frequency on perceptions of disapproval and perceived harm among middle and high school students (N = 522). We found that perceptions of parent disapproval were a better predictor of marijuana use (p = 0.01) than peer disapproval. Perceived harm was related to marijuana use (p = 0.04). Researchers should consider using zero-inflated negative binomial regression models when examining youth drug use.