This paper reviews what is known about the role of neurochemicals in controlling the development of the brain and in the pathophysiology of autism. Suggested approaches to further research involve using animal models, examining effects of drugs on neurochemicals, and using such technologies as positron emission tomography and magnetic resonance…

Research on humans and monkeys is reviewed that supports the view that the medial temporal lobe, and, perhaps more specifically the amygdala, is the neural substrate underlying social deficits in autism. The relationship of early medial temporal lobe lesions to memory and socioemotional behavior is reviewed, as are the roles of the amygdala and…

A method for empirical classification of autistic and autisticlike children, based on behavior observations of 35 males and 11 females (ages 4-28 years) was examined. Factor and cluster analysis indicated four subtypes, characterized by perseverative thinking and play, motor disturbances, schizotypal/schizoid features, and anxiety and negativism.…

This study assessed collateral effects during unstructured dinnertime family interactions of two different paradigms for training parents of 17 children with autism. One taught individual target behaviors serially, and the other taught the pivotal responses (PRT) of motivation and responsivity to multiple cues. Results suggested the PRT…