This paper presents the systems-level changes that were adopted by a school in Mumbai, India, to implement Tier 2 reading interventions. We specifically report on three areas at the micro level of change: universal screening for proactive support, systematic intervention for strategic support, and team collaboration for coordinated support; and four areas at the macro level of change: capable leadership, team capacity, inclusive culture, and continuous improvement. The purpose of this paper is to provide practitioners in the Indian context insight into how to create a sustainable framework for implementing reading interventions at the Tier 2 level.