It is essential that children who are deaf-blind have learning experiences that improve their quality of life. Unfortunately, even when educational teams work together to create individualized education programs, these students do not always have full and equal opportunities to learn. This issue of "Practice Perspectives" describes the basics of Universal Design for Learning (UDL) and how it applies to students who are deaf-blind. The information is intended to help teachers, parents, interveners, and individuals with deaf-blindness better understand UDL so that they can actively participate in the development of UDL practices to improve education for all students.