The Substance Abuse and Mental Health Services Administration (SAMHSA) and its Center for Substance Abuse Prevention (CSAP) are committed to bringing effective substance abuse prevention and behavioral health promotion programs to every community in the Nation. As more knowledge is gained about efficacy and effectiveness of prevention and behavioral health promotion, it becomes more important to make that information available to prevention service providers across the country. This report provides the latest information about individual model programs and important syntheses of research and evaluation findings across multiple prevention programs. It describes a comprehensive system that SAMHSA is using to ensure optimal use of these programs in communities across America. It is expected that this report will be of use to officials at all levels of government; to prevention researchers and practitioners; and to parents, educators, community youth workers, and faith leaders. The report specifically updates current knowledge in five areas that are central to SAMHSAs mission of bringing scientific data to practice settings: progress in identifying SAMHSA's model programs; synthesis of research findings; knowledge dissemination; issues, progress, and future directions in various essential topics of science-based prevention programming; and the latest listing of SAMHSA model programs, effective programs, and promising programs. (GCP)