"Making Sense of Decoding and Spelling: An Adult Reading Course of Study" is an evidence-based course of study designed to teach adult learners to decode and spell words more accurately and fluently. It is designed to be used as one component of a comprehensive adult reading course. The target population for the course is adult basic education (ABE) learners at the low-intermediate level (fourth to seventh grade equivalence level). It contains 30 scripted lesson plans. The course of study begins with a review of basic alphabetic decoding skills and then teaches the most common and useful patterns of English words, and their applications in decoding, spelling, and fluent reading. The course was evaluated in an experimental study. This Teachers' and Administrators' Guide is designed to assist ABE instructors in using the "Making Sense" course of study, and provides information for ABE administrators to use in supporting instruction with "Making Sense". The Lesson Plans document includes the 30 scripted lessons with related charts and overhead transparencies. The Learner Activity Book is designed for use by individual learners in conjunction with the lessons; each learner should have a copy. It is important to have all materials to use the course effectively. All materials are designed to be downloaded from the Internet, printed and copied for use.