This is an empirical study of selected learner characteristics and their relation to academic success, as indicated by course grades, in a structured independent study learning program. This program, called the Audio-Tutorial System, was utilized in an undergraduate college course in the biological sciences. By use of multiple regression analysis, the most stable predictors were found to be the Restraint scale of the Guilford-Zimmerman Temperament Survey, high school rank, SAT-Verbal, CEEB-Mathematics, and high school social studies grade. Limitations on the study include the fact that it was correlational and not experimental and that its sample consisted of volunteers who completed the course. (DG)