This report on substance use is the first presenting State estimates from the 2000 National Household Survey on Drug Abuse (NHSDA). The report presents State estimates for 17 different measures related to substance use. Of these measures, 12 are based on an average for the combined years 1999 and 2000, while the remaining 5 only use the 2000 data. For each measure, States have been ranked and categorized into quintiles in order to simplify the discussion. Specific chapters are dedicated to illicit drug use, alcohol use, tobacco use, and dependence on or abuse of alcohol or illicit drugs. Six appendixes contain tables of model-based estimates, by substance; state estimation methodology; state-by-state-model-based tables; description of the survey; statistical methods and limitations of the data; and other sources of data. The last five appendixes appear under a separate cover in Volume II: Supplementary Technical Appendices. (Contains 14 references and 34 tables.) (GCP)