This study examined the relationships among burnout, academic achievement, and self-regulation with two structural models. The participants were 383 undergraduates with different majors in a university in the western part of Turkey. The results showed that academic achievement was negatively associated with three dimensions of burnout and was positively associated with self-regulation. The results also confirmed that cynicism fully mediated the effect of emotional exhaustion on academic achievement and reduced academic efficacy; academic achievement partially mediated the effect of cynicism on reduced academic efficacy. In addition, analysis revealed that self-regulation partially mediated the effect of emotional exhaustion on cynicism and fully mediated reduced academic efficacy and academic achievement. These findings suggest that self-regulation skills had mediating role relationship between burnout and academic achievement. Implications of these findings are discussed in detail.