Children with autism spectrum disorder (ASD) often exhibit difficulties with acquisition of language and social skills. In this study, the authors evaluate the effects of Enhanced Milieu Teaching (EMT) combined with book reading to teach vocabulary words to young children with ASD during play. Replicating the study procedures of McLeod, Hardy, and Kaiser (2017), two young children with ASD participated in the play-based EMT intervention with book reading three to five times a week. Results indicated that the use of the EMT with book reading was effective in teaching five target words to each child and the obtained language skills were maintained at high levels. After intervention, the parents reported high satisfaction and expectation of long-term benefits of the intervention. Implications for practice and research are discussed.