Although research has established that feelings of not mattering are associated with distress, the factors and processes that contribute to these associations have not received much consideration. The current study was conducted to address three themes. First, mattering was evaluated from a motivational perspective by examining mattering and regulatory focus. Second, the uniqueness of low mattering in predicting distress was investigated when considered along with other predictors (i.e., self-esteem and regulatory focus). Finally, a negative inferential style involving perceptions of negative social feedback was tested as a cognitive mediator of the link between mattering and distress. Mattering was correlated moderately with a promotion self-regulation focus. Regression analyses showed that mattering was also linked uniquely with distress beyond the variance predicted by self-esteem and regulatory focus. In addition, the association between low mattering and distress was mediated by negative social feedback. Our findings highlight the need for further investigation of mattering as a unique contributor to distress and the factors associated with mattering.