The University of North Texas (UNT) has a long-standing partnership with the University of Magallanes (UMAG), Chile. This partnership is unique due to the wide expanse of its activities and connections to the local, regional, national, and international contexts. Moreover, this mutually beneficial partnership and its accompanying and tangential activities and initiatives span student mobility, transnational research, academic partnerships, community engagement, and several UN Sustainable Development Goals. This case study will discuss the various aspects of the partnership, how it developed and flourished over the past 20 years, and the impact of COVID on initiatives to expand global collaboration. It is a fascinating study of how the research interests of two faculty members led the way for UNT to develop an interdisciplinary partnership with regional, national, and international recognition. In particular, the authors will analyze the key ingredients for success of the partnership along with lessons learned. The chapter also will examine how the pandemic created a new dynamic, discuss steps taken to mitigate its impact, and offer some predictions for future directions. [For the complete volume, "Internationalization and Imprints of the Pandemic on Higher Education Worldwide. International Perspectives on Education and Society. Volume 44," see ED674996.]