Ageism, social isolation, and depression are key societal issues that negatively influence mental health as people age. Public health interventions have been developed to reduce these issues and their negative consequences. Intergenerational arts-based programming is an approach that can not only lower rates of loneliness and depression by presenting creative opportunities for participants to socially engage, but one that also offers an experience where participants can better understand individuals of various age cohorts, reducing ageist beliefs and stereotypes. In this qualitative study, the researchers gathered data from art educators regarding their experiences with and suggestions for intergenerational arts-based programs. Participants suggested learning experiences that intergenerational arts-based programs should feature to reduce the incidence and prevalence of ageism, social isolation, and depression among art program participants. An intergenerational arts-based best practice guide was then developed and vetted by art educators and may prove useful for addressing these important public health challenges.