This study investigated whether the big five factors of personality traits can predict academic department chairs' leadership practices. The study had a predictive research design; the data were collected from 424 participants in the 2023 academic year, and the instruments of this study were two questionnaires. The study found that the big five factors of personality traits predict the leadership practices of academic department chairs. Two factors of personality traits, conscientiousness and openness to experience, were statistically significant and predicted the practices in modelling leadership. Four factors (agreeableness, conscientiousness, openness to experience, and extroversion) were statistically significant and predicted leadership practices in inspiring a shared vision. Three factors (neuroticism, extroversion, and conscientiousness) were statistically significant and predicted leadership practices in challenging processes. Two factors (conscientiousness and openness to experience) were statistically significant and predicted leadership practices enabling others to act. Three factors (conscientiousness, agreeableness, and openness to experience) were statistically significant and predicted leadership practices encouraging the heart. The study recommended that academic leaders be required to consider personality traits as an important dimension in selecting and assigning academic department chairs and other academic leaders at all levels at higher education institutions.