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Identifying Loci for the Overlap between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Using a Genome-Wide QTL Linkage Approach
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Nijmeijer, Judith S.; Arias-Vasquez, Alejandro; Rommelse, Nanda N. J.; Altink, Marieke E.; Anney, Richard J. L.; Asherson, Philip; Banaschewski, Tobias; Buschgens, Cathelijne J. M.; Fliers, Ellen A.; Gill, Michael; Minderaa, Ruud B.; Poustka, Luise; Sergeant, Joseph A.; Buitelaar, Jan K.; Franke, Barbara; Ebstein, Richard P.; Miranda, Ana; Mulas, Fernando; Oades, Robert D.; Roeyers, Herbert; Rothenberger, Aribert; Sonuga-Barke, Edmund J. S.; Steinhausen, Hans-Christoph; Faraone, Stephen V.; Hartman, Catharina A.; Hoekstra, Pieter J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: The genetic basis for autism spectrum disorder (ASD) symptoms in children with attention-deficit/hyperactivity disorder (ADHD) was addressed using a genome-wide linkage approach. Method: Participants of the International Multi-Center ADHD Genetics study comprising 1,143 probands with ADHD and 1,453 siblings were analyzed. The total and…
Descriptors: Attention Deficit Hyperactivity Disorder, Siblings, Autism, Genetics
Family-Based Genome-Wide Association Scan of Attention-Deficit/Hyperactivity Disorder
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Mick, Eric; Todorov, Alexandre; Smalley, Susan; Hu, Xiaolan; Loo, Sandra; Todd, Richard D.; Biederman, Joseph; Byrne, Deirdre; Dechairo, Bryan; Guiney, Allan; McCracken, James; McGough, James; Nelson, Stanley F.; Reiersen, Angela M.; Wilens, Timothy E.; Wozniak, Janet; Neale, Benjamin M.; Faraone, Stephen V. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of…
Descriptors: Evidence, Attention Deficit Hyperactivity Disorder, Quality Control, Genetics
Progress in Cytogenetics: Implications for Child Psychopathology
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Hoffman, Ellen J.; State, Matthew W. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: This review considers the impact of chromosomal studies on the understanding of childhood neuropsychiatric syndromes, highlighting key discoveries, advances in technology, and new challenges faced by clinicians trying to interpret recent findings. Method: We review the literature on the genetics of child psychiatric disorders, including…
Descriptors: Attention Deficit Hyperactivity Disorder, Investigations, Schizophrenia, Emotional Disturbances
Familial Clustering and DRD4 Effects on Electroencephalogram Measures in Multiplex Families with Attention Deficit/Hyperactivity Disorder
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Loo, Sandra K.; Hale, T. Sigi; Hanada, Grant; Macion, James; Shrestha, Anshu; McGough, James J.; McCracken, James T.; Nelson, Stanley; Smalley, Susan L. – Journal of the American Academy of Child & Adolescent Psychiatry, 2010
Objective: The current study tests electroencephalogram (EEG) measures as a potential endophenotype for attention deficit/hyperactivity disorder (ADHD) by examining sibling and parent-offspring similarity, familial clustering with the disorder, and association with the dopamine receptor D4 (DRD4) candidate gene. Method: The sample consists of 531…
Descriptors: Attention Deficit Hyperactivity Disorder, Siblings, Medicine, Genetics
Genetic Overlap between Measures of Hyperactivity/Inattention and Mood in Children and Adolescents
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Cole, James; Ball, Harriet A.; Martin, Neilson C.; Scourfield, Jane; McGuffin, Peter – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Evidence suggests that there is substantial comorbidity between attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder in childhood and adolescence. This study aims to investigate the degree to which etiological factors are shared between the symptoms of these significantly heritable disorders. Method: A twin…
Descriptors: Evidence, Attention Deficit Hyperactivity Disorder, Twins, Females
A Candidate Gene Analysis of Methylphenidate Response in Attention-Deficit/Hyperactivity Disorder
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McGough, James J.; McCracken, James T.; Loo, Sandra K.; Manganiello, Marc; Leung, Michael C.; Tietjens, Jeremy R.; Trinh, Thao; Baweja, Shilpa; Suddath, Robert; Smalley, Susan L.; Hellemann, Gerhard; Sugar, Catherine A. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD). Method: Eighty-two subjects with ADHD aged 6 to 17 years participated in a prospective, double-blind, placebo-controlled, multiple-dose, crossover titration trial of…
Descriptors: Attention Deficit Hyperactivity Disorder, Mathematics Tests, Factor Analysis, Genetics
Attention Deficit Hyperactivity Disorder with Reading Disabilities: Preliminary Genetic Findings on the Involvement of the ADRA2A Gene
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Stevenson, J.; Langley, K.; Pay, H.; Payton, A.; Worthington, J.; Ollier, W.; Thapar, A. – Journal of Child Psychology and Psychiatry, 2005
Background: Attention deficit/hyperactivity disorder (ADHD) and reading disability (RD) tend to co-occur and quantitative genetic studies have shown this to arise primarily through shared genetic influences. However, molecular genetic studies have shown different genes to be associated with each of these conditions. Neurobiological studies have…
Descriptors: Evidence, Attention Deficit Hyperactivity Disorder, Reading Difficulties, Genetics
Bivariate Linkage Scan for Reading Disability and Attention-Deficit/Hyperactivity Disorder Localizes Pleiotropic Loci
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Gayan, J.; Willcutt, E. G.; Fisher, S. E.; Francks, C.; Cardon, L. R.; Olson, R. K.; Pennington, B. F.; Smith, S. D.; Monaco, A. P.; DeFries, J. C. – Journal of Child Psychology and Psychiatry, 2005
Background: There is a growing interest in the study of the genetic origins of comorbidity, a direct consequence of the recent findings of genetic loci that are seemingly linked to more than one disorder. There are several potential causes for these shared regions of linkage, but one possibility is that these loci may harbor genes with manifold…
Descriptors: Attention Deficit Hyperactivity Disorder, Genetics, Reading Difficulties, Disabilities
Introductory Guide to the Statistics of Molecular Genetics
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Eley, Thalia C.; Rijsdijk, Fruhling – Journal of Child Psychology and Psychiatry, 2005
Background: This introductory guide presents the main two analytical approaches used by molecular geneticists: linkage and association. Methods: Traditional linkage and association methods are described, along with more recent advances in methodologies such as those using a variance components approach. Results: New methods are being developed all…
Descriptors: Attention Deficit Hyperactivity Disorder, Control Groups, Genetics, Effect Size