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Genetic Association of Lipids and Lipid-Lowering Drug Target Genes with Attention Deficit Hyperactivity Disorder
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Detong Guo; Wenchao Sheng; Yingzi Cai; Jianbo Shu; Chunquan Cai – Journal of Attention Disorders, 2024
Background: Lipid metabolism plays an essential role in nervous system development. Cholesterol deficiency leads to a variety of neurodevelopmental disorders, such as autism spectrum disorder and fragile X syndrome. There have been a lot of efforts to search for biological markers associated with and causal to ADHD, among which lipid is one…
Descriptors: Attention Deficit Hyperactivity Disorder, Genetic Disorders, Metabolism, Biochemistry
DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders
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Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Are Some Individuals Diagnosed with ADHD Prone to Alcohol Abuse?: Consideration of Two Possible Mediating Factors for this Susceptibility
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Maxwell, Allison – Journal of Attention Disorders, 2013
Some studies conducted on ADHD have found a statistically significant relationship between those diagnosed with the disorder and a higher susceptibility to abuse alcohol. However, other studies have found no such correlation, or have found this to be true of only a nonstatistically significant subset of the population of individuals with ADHD.…
Descriptors: Attention Deficit Hyperactivity Disorder, Alcohol Abuse, Genetics, Brain
Diagnosis of Attention-Deficit/Hyperactivity Disorder and Its Behavioral, Neurological, and Genetic Roots
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Mueller, Kathryn L.; Tomblin, J. Bruce – Topics in Language Disorders, 2012
Attention-deficit/hyperactivity disorder (ADHD) is a common developmental disorder often associated with other developmental disorders including speech, language, and reading disorders. Here, we review the principal features of ADHD and current diagnostic standards for the disorder. We outline the ADHD subtypes, which are based upon the dimensions…
Descriptors: Attention Deficit Hyperactivity Disorder, Genetics, Executive Function, Brain Hemisphere Functions
Lack of Association between a 3'UTR VNTR Polymorphism of Dopamine Transporter Gene (SLC6A3) and ADHD in a Brazilian Sample of Adult Patients
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Aperecida da Silva, Maria; Cordeiro, Quirino; Louza, Mario; Vallada, Homero – Journal of Attention Disorders, 2011
Objective: To investigate a possible association between a 3'UTR VNTR polymorphism of the dopamine transporter gene (SLC6A3) and ADHD in a Brazilian sample of adult patients. Method: Study Case-control with 102 ADHD adult outpatients ("DSM-IV" criteria) and 479 healthy controls. The primers' sequence used were: 3'UTR-Forward: 5' TGT GGT…
Descriptors: Attention Deficit Hyperactivity Disorder, Patients, Adults, Correlation
Association of the DAT1 Genotype with Inattentive Behavior Is Mediated by Reading Ability in a General Population Sample
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Cornish, Kim M.; Savage, Robert; Hocking, Darren R.; Hollis, Chris P. – Brain and Cognition, 2011
Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) frequently co-occur in the child population and therefore raise the possibility of shared genetic etiology. We used a quantitative trait loci (QTL) approach to assess the involvement of the dopamine transporter (DAT1) gene polymorphism in mediating reading disability and…
Descriptors: Attention Deficit Hyperactivity Disorder, Age, Etiology, Reading Ability
Pharmacogenetic Predictors of Methylphenidate Dose-Response in Attention-Deficit/Hyperactivity Disorder
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Froehlich, Tanya E.; Epstein, Jeffery N.; Nick, Todd G.; Melguizo Castro, Maria S.; Stein, Mark A.; Brinkman, William B.; Graham, Amanda J.; Langberg, Joshua M.; Kahn, Robert S. – Journal of the American Academy of Child & Adolescent Psychiatry, 2011
Objective: Because of significant individual variability in attention-deficit/hyperactivity disorder (ADHD) medication response, there is increasing interest in identifying genetic predictors of treatment effects. This study examined the role of four catecholamine-related candidate genes in moderating methylphenidate (MPH) dose-response. Method:…
Descriptors: Attention Deficit Hyperactivity Disorder, Rating Scales, Drug Therapy, Identification
The Impact of Polyunsaturated Fatty Acids in Reducing Child Attention Deficit and Hyperactivity Disorders
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Transler, Catherine; Eilander, Ans; Mitchell, Siobhan; van de Meer, Nelly – Journal of Attention Disorders, 2010
Objectives: To review the impact of polyunsaturated fatty acids (PUFA) in reducing ADHD symptoms in children. Methods: Peer-reviewed experimental literature published from 1980 to Mai 2009 is consulted (Psychinfo, Medline, and resulting reference lists). Results: Placebo-controlled studies with ADHD or hyperactive children show no effects on…
Descriptors: Attention Deficit Hyperactivity Disorder, Attention Deficit Disorders, Neurology, Nutrition